-----Amy Lysle Smart was born in Topanga, California and studied ballet for ten years.
While modelling in Italy, Smart met fellow model Ali Larter and the two "became instant friends." Back in Los Angeles, the two took acting classes together.
Smart's first film role was in director Martin Kunert's film Campfire Tales, followed by a small role as Queenie in the 1996 rendition of John Updike's short story, "A&P.” She also had a minor role in the 1997 film Starship Troopers. She then starred in the mini-series The 70s, playing a young woman from Ohio.
In 1999, Smart played the girlfriend of a popular American football player in the film Varsity Blues - which also re-united her with Larter. Smart played a recurring character on the series Felicity from 1999 to 2001 — Ruby, a former girlfriend of Scott Foley's character.
In 2000, she co-starred in the films Road Trip - which featured Amy in an erotic sexual romp - followed by Rat Race, Starsky & Hutch, and The Butterfly Effect. In 2003 Smart also had a small role in the American sitcom Scrubs, playing Jamie Moyer (aka "Tasty Coma Wife,") one of main character J.D.'s love interests.
In 2005, Smart co-starred with Ryan Reynolds in the romantic comedy film Just Friends. That same year, Smart starred as Sarah in a British independent film called The Best Man.
She also appeared in the 2006 film Crank, portraying the girlfriend of the lead character, Chev Chelios - played by Jason Statham. In the film, they have sex amidst a crowd of onlookers. She reprised the role in the sequel, Crank: High Voltage, released in 2009.
Smart was a regular cast member in the short-lived 2006 CBS television series Smith. She also has voiced some of the characters in the animated series Robot Chicken, created by Seth Green.
Smart appeared as Joy in the 2006 movie Peaceful Warrior, starring Scott Mechlowicz and Nick Nolte. She also starred as Melissa in the 2008 independent film Seventh Moon. In 2009, she starred in Love 'N Dancing where her character, Jessica, enters the World Swing Dance Championships.
In 2011, Smart joined the Showtime drama/comedy Shameless as the recurring character Jasmine Hollander.
A vegetarian, Amy was named #74 in FHM magazine's "100 Sexiest Women in the World 2006" supplement, and ranked #31 on the Maxim magazine Hot 100 of 2007 list.